Furthermore, siRNA-mediated silencing or plasmid-mediated upregulation of FBW7 resulted in altered epithelial-mesenchymal transition (EMT) patterns in NSCLC cells. Results: We found that FBW7 upregulation significantly increased cisplatin chemosensitivity and that cells expressing low levels of FBW7, such as NCI-H1299 cells, have a mesenchymal phenotype. Methods: We used cell viability assays, Western blotting, and immunofluorescence combined with siRNA interference or plasmid transfection to investigate the underlying mechanism of cisplatin resistance in NSCLC cells. FBW7 also functions as a tumor suppressor. F-box/WD repeat-containing protein 7 (FBW7) is a member of the F-box protein family that regulates cell cycle progression, and cell growth and differentiation. Cisplatin-based multidrug chemotherapy regimen is standard for such lesions, but drug resistance is an increasing problem. Approximately 80% of lung cancers are classified as non-small cell lung cancers (NSCLCs). Introduction: Lung cancer is extremely harmful to human health and has one of the highest worldwide incidences of all malignant tumors. This study also highlighted the utility of HRQoL assessment for prognostic evaluation of patients after surgical treatment for bone cancer. Conclusion: The HRQoL of patients with malignant bone tumors greatly improved one year after the treatment. Age and type of surgery were associated with HRQoL in the mental domain. However, the patients still had significantly lower scores in every domain than the reference group one year after discharge. Results: All 8 domains of HRQoL had the lowest scores greatly improved over the first year after discharge. The HRQoL before treatment and after one year was evaluated with the Medical Outcome Short Form 36 (SF-36). All 344 patients were followed up for one year. 2011, and a reference group with 361 health cases was recruited in the same hospital during the same period. Methods: 344 eligible adult patients who were admitted to the hospital with malignant bone tumors during the period of Jun. Journal of Industrial and Engineering Chemistry (2)Īim: We conducted the present study to assess health-related quality of life (HRQoL) among bone cancer patients after surgical treatment in one large teaching hospitals in China, and assess the risk factors for improving the physical or mental HRQoL.Structural monitoring and maintenance (2).Journal of Acupuncture & Meridian Studies (2).The Korean Journal of Physiology & Pharmacology (2).Journal of the optical society of Korea (2).Journal of communications and networks (2).Journal of Ceramic Processing Research (2).International Journal of Steel Structures (2).Applied Biological Chemistry (Appl Biol Chem) (2).International Journal of Multimedia and Ubiquitous (2).International Journal of Aeronautical and Space Sc (2).IEEE transactions on plasma science (2).Journal of biochemistry and molecular biology (3).International Journal of Signal Processing (3).Journal of Advanced Smart Convergence (3).JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - (3).Structural Engineering and Mechanics (4).Journal of Electrical Engineering & Technology (4).International Journal of Concrete Structures and M (4).International Journal of Hybrid Information Techno (5).Journal of information processing systems (5).Experimental and molecular medicine (5).The Koreran journal of Endocrine Surgery (6).Journal of Neurogastroenterology and Motility (JNM (6).Biotechnology and Bioprocess Engineering (6).THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY (9).Journal of Computing Science and Engineering (10).International Journal of Precision Engineering and (10).Korean Journal of Chemical Engineering (10).Journal of Asia-Pacific Entomology (11).Nuclear Engineering and Technology (12).Bulletin of the Korean Chemical Society (12).KSII Transactions on Internet and Information Syst (14).JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY (15).Journal of microbiology and biotechnology (27).Asian Pacific journal of cancer prevention (114).
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